About this role
Neurocrine Biosciences is a leading biopharmaceutical company dedicated to relieving suffering for people with great needs. We discover and develop life-changing treatments for under-addressed neurological, psychiatric, endocrine, and immunological disorders.
As Senior Principal Scientist, you will provide Clinical Pharmacology scientific support for one or more clinical development programs. You will lead the planning, execution, interpretation, and communication of Clinical Pharmacology activities, contributing to dose selection and study design across a diverse portfolio.
You will represent Clinical Pharmacology on cross-functional teams, coordinating with Pharmacometrics, Clinical, Biostatistics, and Regulatory colleagues. Your work will ensure high-quality deliverables and recommendations that enable development and regulatory decision-making.
This role offers the opportunity to apply unique insights into neuroscience and the interconnections between brain and body systems. You will contribute to a robust pipeline including multiple compounds in mid- to late-phase clinical development across core therapeutic areas.
Requirements
- PhD in Pharmaceutical Sciences, Pharmacology, or a related field
- Expertise in pharmacokinetic and pharmacodynamic data analysis and interpretation
- Experience with clinical pharmacology study design and execution across multiple therapeutic areas
- Knowledge of regulatory guidelines (FDA, EMA) for clinical pharmacology in drug development
- Strong track record of scientific publications and presentations in clinical pharmacology
- Ability to lead cross-functional teams and influence development and regulatory decision-making
Responsibilities
- Contribute to the development and execution of Clinical Pharmacology strategies for assigned programs or therapeutic areas, aligned with overall development plans
- Lead the planning, conduct, interpretation, and reporting of pharmacokinetic (PK), pharmacodynamic (PD), and exposure–response activities for clinical development compounds
- Serve as the Clinical Pharmacology representative on cross-functional program teams, providing scientific input to protocol design, dose selection, and study interpretation across development stages
- Oversee the preparation and review of clinical pharmacology sections for regulatory documents and submissions
- Design and oversee clinical pharmacology studies including food-effect, drug-drug interaction, and special population studies
- Provide modeling and simulation support for dose selection and optimization across therapeutic modalities
Benefits
- Contribute to life-changing treatments for under-addressed neurological, psychiatric, endocrine, and immunological disorders
- Work on a robust pipeline including multiple compounds in mid- to late-phase clinical development
- Collaborate with cross-functional teams including Pharmacometrics, Clinical, Biostatistics, and Regulatory
- Be part of a company with over three decades of unique insight into neuroscience and brain-body connections
Similar roles
Medical Science Liaison - Oncology
4w4 weeks agoAmgen
Houston, US · Full-time · $156,998 – $212,410
Area Director of Clinical Operations - Remote
4w4 weeks agoFlorida Cancer Specialists & Research Institute
US · Full-time · $120,000 – $150,000
Medical Science Liaison
4w1 month agoNeoGenomics Laboratories
US · Full-time · $130,000 – $160,000
Executive Director Clinical Pharmacology
4w1 month agoRegeneron
Tarrytown, US · Full-time · $285,600 – $475,900