About this role
Astellas is a global life sciences company committed to turning innovative science into value for patients. We provide transformative therapies in oncology and other disease areas with high unmet medical need. The Senior Research Associate supports pioneering oncology research at the Tsukuba site.
This pharmacologist role develops anti-cancer drugs including antibody-drug conjugates, multi-specific antibodies, and engineered small molecules. Daily work centers on planning and executing non-clinical pharmacological studies to advance discovery projects.
The Discovery Tumor Microenvironment group leads Astellas Oncology Research by leveraging single-cell and spatial transcriptome analysis plus multiplex IHC. Collaboration with academic partners at Kashiwa-no-ha TME iLab drives target identification from clinical samples.
Candidates thrive in dynamic environments, embrace new ideas, and act with integrity to deliver tangible patient impact. The permanent position offers the chance to help shape next-generation oncology therapies.
Requirements
- Pharmacologist with experience conducting in vivo animal studies
- Knowledge of oncology drug discovery including ADCs and multi-specific antibodies
- Familiarity with single-cell and spatial transcriptome technologies
- Ability to design studies that confirm mechanism of action and select candidates
- Strong motivation to work in a cutting-edge research environment
Responsibilities
- Plan and conduct non-clinical pharmacological studies including animal studies to advance oncology projects
- Identify and select drug candidates through appropriate experimental design
- Confirm mechanism of action for antibody-drug conjugates and multi-specific antibodies
- Estimate human dose projections from non-clinical data
- Apply single-cell transcriptome analysis and spatial transcriptome analysis on clinical samples
- Perform multiplex IHC to validate novel therapeutic targets in the tumor microenvironment
Benefits
- Permanent employment
- Opportunity to collaborate with academic partners at Kashiwa-no-ha TME iLab
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