Vice President, Medical Affairs

4w4 weeks ago

Lexeo Therapeutics

New York City, US · Full-time · $280,000 – $380,000

About this role

Lexeo Therapeutics is seeking a Vice President, Medical Affairs to provide enterprise-level leadership across our gene therapy program. Reporting to the Chief Medical Officer, this role will set the strategic direction for Medical Affairs, overseeing scientific communications, congress strategy, external expert engagement, medical information, medical evidence generation, and medical education.

In this role, you will shape and scale the Medical Affairs function, build organizational capabilities, and drive external scientific leadership in support of Lexeo's development and future commercialization objectives. You will serve as a senior cross-functional leader and strategic partner to Clinical Development, Regulatory, and Patient Advocacy teams.

The ideal candidate is a strategic, hands-on leader who thrives in a dynamic, high-growth environment and can influence across the organization and external stakeholders. You will build, mentor, and lead a high-performing Medical Affairs organization, including external partners and future in-house team members.

This is an opportunity to drive the development of onboarding, scientific training, and internal medical education initiatives to elevate organizational disease-area expertise. You will represent Lexeo externally at major scientific meetings, investigator forums, and executive-level partner interactions.

Requirements

Advanced degree in life sciences, medicine, or a related field required (MD, PharmD, PhD preferred) with 10+ years of industry experience
Significant Medical Affairs leadership experience in biotechnology or pharmaceuticals, with demonstrated progression in scope and responsibility
Deep expertise in scientific communications, external expert engagement, medical strategy, and cross-functional collaboration
Experience building or scaling Medical Affairs capabilities in a growth-stage organization, especially transitioning from clinical stage to commercialization, is strongly preferred
Strong executive presence with excellent written and verbal communication skills and the ability to influence senior internal and external stakeholders
Ability to operate strategically while remaining hands-on in a fast-paced, evolving environment

Responsibilities

Define and lead the global Medical Affairs strategy across Lexeo's portfolio, ensuring alignment with development milestones and business objectives
Build, mentor, and lead a high-performing Medical Affairs organization, including external partners and future in-house team members
Own scientific communications strategy, including publications planning, congress strategy, medical education, and dissemination of clinical and disease-state insights
Establish and oversee external engagement strategy with key opinion leaders, investigators, medical societies, and patient advocacy organizations
Serve as the senior Medical Affairs representative in cross-functional governance, partnering with Clinical Development, Regulatory, Market Access, and Patient Advocacy leaders
Guide medical input into clinical development plans, patient identification strategies, launch readiness planning, and evidence-generation priorities
Oversee medical review processes and ensure high-quality, compliant externally facing scientific content and response materials
Lead advisory board strategy and execution, translating stakeholder insights into actionable plans for development and commercialization

Benefits

Leadership role in a high-growth gene therapy company
Opportunity to shape and scale a Medical Affairs function from clinical stage to commercialization
Senior cross-functional influence across Clinical Development, Regulatory, and Patient Advocacy
External scientific leadership at major medical meetings and executive-level partner interactions