Postdoc - AAV Vectors

2w2 weeks ago

Boehringer Ingelheim

Biberach an der Riß, DE · Temporary · €55,000 – €65,000

About this role

Join a cutting-edge research team advancing drug target validation through next-generation vector technologies. As a Postdoctoral Scientist, engineer and characterize Adeno-associated virus (AAV) vectors for tissue-specific or pan-tissue gene modulation. Contribute to novel therapeutic concepts in early research within a dynamic pharma environment.

Conceive strategies for identifying pan-tissue transducing AAV vectors using in silico design, directed evolution or combinatorial approaches. Produce, purify and analyze AAV preparations while conducting in vivo studies in mice to select promising candidates. Apply DNA-, RNA- and protein-based readouts like qPCR, in situ hybridization, sequencing and immunohistochemistry.

Modulate genes through overexpression, knockdown or CRISPR-knockouts to explore and validate drug targets in early NCE/NBE drug discovery. Collaborate with multidisciplinary experts in an international team. Work in Boehringer Ingelheim's innovation-driven research setting in Biberach.

This 2-year limited position is part of Boehringer’s global postdoctoral program. Present your work at the Boehringer Postdoc days. Note: Open to all qualified candidates, not just recent PhD graduates.

Requirements

PhD degree in molecular biology, biotechnology, biochemistry or related discipline
Profound knowledge of molecular and cell biological techniques
Experience in animal and/or tissue handling is a plus
In-depth knowledge and hands-on experience with AAV vectors or other viral vector systems
Demonstrated expertise in capsid engineering is a strong advantage
Confidence in handling complex and large data sets
Track record of publications in peer-reviewed journals
Ability to work in a multidisciplinary and international team with excellent written and oral communication skills
Fluency in English spoken and written; German is a plus

Responsibilities

Conceive strategies for identification of pan-tissue transducing AAV vectors, including in silico design, directed evolution or combinatorial approaches
Produce, purify and analyze AAV preparations
Conduct in vivo studies to select and characterize promising vector candidates in mice
Apply DNA-, RNA- and protein-based readouts such as qPCR, in situ hybridization, sequencing and immunohistochemistry
Modulate genes (overexpression, knockdown, CRISPR-knockouts) to explore and validate drug targets in early NCE/NBE drug discovery research
Participate in Boehringer’s global postdoctoral program
Present work at the Boehringer Postdoc days