Vice President, Preclinical Development

1w1 week ago

Scripps Research

San Diego, US · Full-time · $303,600 – $322,000

About this role

Calibr-Skaggs Institute for Innovative Medicines, a division of Scripps Research, accelerates new medicines by pairing biomedical research with drug discovery capabilities. Ranked the most influential institution for innovation, it advances nonprofit translational research across diseases like cancer and autoimmunity. The Vice President, Preclinical Development leads in vivo pharmacology, efficacy, toxicology, and ADME/PK to advance novel therapeutics.

This senior on-site role integrates pharmacology across research and development programs from discovery through IND filing and early clinical stages. The leader provides strategic oversight for candidate selection, dose selection, and clinical translation using pharmacology data. Responsibilities span multidisciplinary collaboration and regulatory compliance.

Partner closely with chemistry, biology, DMPK, CMC, regulatory, and clinical teams for efficient program advancement. Oversee multiple CROs for outsourced activities, ensuring quality, timelines, and budgets. Build and mentor a high-performing team fostering scientific rigor and collaboration.

Join a transformative team shaping pharmacology strategy across multiple programs. Impact patients through a portfolio spanning infectious diseases, metabolic disorders, and neurodegeneration. Leverage Scripps Research's unique environment to reinvest in innovative biomedical research.

Requirements

Deep scientific expertise in in vivo pharmacology, efficacy, toxicology, and ADME/PK
Strong people leadership and team-building skills
Proven track record of translational success in small molecule drug development
Proven track record of translational success in biologics drug development
Experience advancing early-stage therapeutic candidates from discovery through IND filing
Expertise in designing and interpreting preclinical studies for clinical translation
Experience managing CROs for pharmacology and toxicology studies
Knowledge of GLP/GMP compliance and regulatory interactions for IND submissions

Responsibilities

Provide scientific and strategic leadership for all in vivo pharmacology, efficacy, toxicology, and ADME/PK activities
Lead pharmacology efforts across the full R&D continuum from target validation and lead optimization through IND-enabling studies
Design, interpret, and integrate pharmacology and toxicology data to inform candidate selection, dose selection, and clinical translation
Partner closely with chemistry, biology, DMPK, CMC, regulatory, and clinical teams to ensure cohesive program advancement
Ensure key activities are conducted in compliance with GLP and GMP regulations
Serve as a key contributor to IND filings, regulatory interactions, and development strategy
Oversee and manage multiple CROs supporting outsourced pharmacology, toxicology, and ADME/PK activities
Build, mentor, and lead a high-performing team, fostering scientific rigor, collaboration, and accountability

Benefits

Join a transformative team at Scripps Research, ranked most influential for innovation
Impact patients through drug portfolio in cancer, autoimmunity, infectious diseases, and more
Shape a new paradigm for nonprofit biomedical research reinvesting in innovation
Leverage world-class biomedical research environment for profound wellbeing advancements