Scientist - Preclinical Operations

1w1 week ago

Ardelyx

Newark, US · Full-time · $131,000 – $160,000

About this role

Ardelyx is a publicly traded biopharmaceutical company with a mission to discover, develop, and commercialize innovative medicines for unmet needs. It has U.S. approvals for IBSRELA® (tenapanor) and XPHOZAH® (tenapanor), plus international agreements. The Scientist, Preclinical Operations joins the drug discovery team to advance GI and cardiorenal programs.

This role coordinates and monitors contract research organizations (CROs) to evaluate drug targets and mechanisms in GI and cardiorenal pathophysiology. It supports development of translational and biomarker strategies across multiple drug programs. Daily work includes outsourcing in vivo models to generate key datasets.

The position collaborates with CROs, academic institutions, and key opinion leaders in disease areas. It integrates into a dynamic, cross-functional team environment focused on high-quality research. Execution emphasizes timely and organized research plans.

Opportunities include scientific due diligence, preclinical de-risking, and generating IND-enabling data. The role authors reports for IND submissions and prepares presentations for internal discussions. It drives company discovery and development efforts forward.

Requirements

Ph.D. in biology, pharmacology, or related discipline with 2-5 years of related experience or equivalent
Experience outsourcing work to CROs located in the US or abroad
Prior experience in the pharmaceutical or biotechnology industry preferred
Experience or knowledge in gut physiology, including the role of intestinal receptors and transporters, desirable
Strong commitment to high-quality research and timely, organized execution of research plans
Excellent written and verbal communication skills, with the ability to collaborate effectively in a dynamic, cross-functional team environment

Responsibilities

Identify, establish, and manage collaborations with CROs, academic institutions, and key opinion leaders in relevant disease areas
Assist with the development and execution, through CROs, of relevant in vivo models critical for evaluating compound activity and mechanism of action
Review, analyze, and summarize data; prepare high-quality presentations for internal discussions
Support drug discovery efforts, including scientific due diligence and preclinical de-risking of GI/cardiorenal opportunities
Collaborate with drug development teams to generate IND-enabling data
Track project resources and invoices
Author scientific reports and supporting documentation for IND submissions