Scientist - Medicinal Chemistry

2w2 weeks ago

Amgen

South San Francisco, US · Full-time · $128,577 – $173,957

About this role

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve pioneered biotech against tough diseases, focusing on Oncology, Inflammation, General Medicine, and Rare Disease.

In this vital role, be part of an innovative Medicinal Chemistry group. Responsibilities include the design, synthesis, and purification of novel compounds for potential clinical drug development. Work within Amgen’s Induced Proximity Platform (IPP) on PROTAC modalities for intractable targets.

This is an onsite laboratory position at our South San Francisco site. Our award-winning culture is collaborative, innovative, and science-based. Thrive with a passion for challenges and opportunities within the team.

Help research, manufacture, and deliver innovative medicines to help people live longer, fuller, happier lives. As a lab leader, contribute to advancing projects. Join us and transform the lives of patients while transforming your career.

Requirements

Doctorate Degree or Master’s degree and 2 years of laboratory experience or Bachelor’s degree and 4 years of laboratory experience
Track record of accomplishments (e.g., peer-reviewed publications)
Demonstrated ability to scout and troubleshoot synthetic routes, and perform high difficulty synthetic chemistry
Clear understanding of structural determination using NMR and Mass Spectral techniques as well as knowledge of purification methods
Demonstration of good lab practices, with particular attention to safety
Excellent communication skills (both written and oral), leadership skills and the ability to work well in teams

Responsibilities

Develop, implement, and perform organic reactions for Medicinal Chemistry teams, including troubleshooting synthetic routes and reactions
Scout new synthetic routes and perform high difficulty synthetic chemistry
Contribute to the design of new compounds and the development of structure-activity relationships
Perform structural determinations using NMR and mass spectral techniques
Purify compounds using a variety of techniques
Serve as a lab leader and demonstrate excellent verbal and written communication skills
Maintain laboratory notebooks, participate in group and project meetings
Present to groups and aid in the writing of papers and patent applications