About this role
Headquartered in Carlsbad, California, Ionis has discovered medical breakthroughs for more than three decades. Pioneers in RNA-targeted medicines, our platform revolutionizes drug discovery and transforms lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology and cardiology, we advance RNA therapies and gene editing.
We seek a motivated Senior Scientist for our Medicinal Chemistry team to synthesize ligands or nucleoside monomers. Incorporate them into therapeutic oligonucleotides and perform bioconjugation to ligands targeting cell surface receptors. This role contributes directly to breakthrough therapies.
At Ionis, we cultivate a challenging, motivating environment fostering innovation and scientific excellence. Our success stems from exceptional employee talents and dedication. We invest in onsite, hybrid, and remote work environments where relationships thrive and culture flourishes.
Join our exceptional team with diverse perspectives to change human health. Passionate about meaningful patient impact? Experience our unique culture while developing your career.
Requirements
- Ph.D. in Organic or Nucleic Acid Chemistry with at least 2 years of post-doctoral experience in academia or industry
- Experience in nucleoside/oligonucleotide synthesis and purification
- Experience with purification techniques (e.g., ion exchange, reverse-phase, and size-exclusion chromatography)
- Experience with automated lab equipment (e.g., NMR, LC-MS)
- Track record of scientific productivity as evidenced by high quality publications and/or patents
- Excellent communication skills and ability to succeed in a team environment
- Ability to be productive in a fast-paced, interactive, and innovative work environment
Responsibilities
- Synthesize ligands or nucleoside monomers
- Incorporate ligands or nucleoside monomers into therapeutic oligonucleotides
- Perform bioconjugation of oligonucleotides to ligands targeting cell surface receptors
- Purify nucleosides or oligonucleotides using ion exchange, reverse-phase, and size-exclusion chromatography
- Characterize compounds with automated lab equipment such as NMR and LC-MS
- Collaborate with cross-functional teams on research and development
- Contribute to innovation in RNA-targeted therapies
Benefits
- Excellent benefits package
- Onsite, hybrid, and remote work environments
- Challenging, motivating, and rewarding environment fostering innovation
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