Principal Scientist - Primary Pharmacology

1w1 week ago

Pfizer

Groton, US · Full-time · $106,000 – $176,600

About this role

At Pfizer, our purpose is to deliver breakthroughs that transform patients' lives. Our Research and Development team translates advanced science into impactful therapies and vaccines. In this role, you will align daily activities with quality commitments to accelerate best-in-class medicines globally.

The successful candidate joins the Discovery Biology and Pharmacology group in Groton, CT. Combine pharmacology and target biology expertise to support hit identification and lead optimization for small molecule drug discovery. Develop hit identification strategies and execute in vitro plate-based screen assays.

Investigate mechanistic pharmacology while collaborating closely with discovery biology, structural biology, and chemistry teams. Support a broad portfolio in Internal Medicine disease indications. Work cross-disciplinary to advance projects effectively.

Maintain knowledge of state-of-the-art technical developments and apply them innovatively. Analyze data, communicate findings clearly to project teams, and build strong partnerships. Thrive in a team-oriented environment driving early discovery efforts.

Requirements

BA/BS and 12 years or MS and 9 years or PhD and 4 years of relevant experience in biochemistry, cell biology and/or pharmacology
Demonstrated expertise with multiple in vitro assay formats (e.g. HTRF, ELISA, FP, BRET, etc) including assay troubleshooting and development
Practical experience with immortalized and primary cells and with molecular biology techniques such as RT-qPCR, transfection, and western blotting
Experience in laboratory automation and data analysis systems
Highly motivated, highly organized and possess excellent computer, verbal and written communication skills
Demonstrated ability to forge strong collaborative relationships inside and outside immediate team as well as cross disciplines
Experience mentoring junior colleagues

Responsibilities

Shape and support novel hit identification and optimization for small molecule drug discovery projects through in vitro pharmacology strategies for target-based and phenotypic projects
Independently design, develop, and perform in vitro assays to drive lead identification, SAR, and mechanistic pharmacology using biochemical and cellular systems
Design creative experiments and leverage diverse approaches to investigate target engagement, structure-function relationships, and molecular mechanism of action
Maintain a strong knowledge base in state-of-the-art technical developments and scientific advancements and apply these innovatively to advance internal capabilities
Analyze and interpret data and communicate clearly to collaborators and project teams as a representative
Collaborate with cross-disciplinary groups including Disease Biology, Chemistry, Computational Biology, and Structural Biology, building partnerships in a team-oriented manner