Senior Scientist - Medicinal Chemistry

1w1 week ago

argenx

Gent, BE · Full-time · €85,000 – €120,000

About this role

Join argenx as we transform immunology and deliver medicines that help autoimmune patients get their lives back. We are establishing a new department dedicated to small molecule and peptide drug discovery. Play a pivotal role in shaping this capability and advancing preclinical projects.

Lead discovery projects by partnering with lead biologists to progress programs from hit identification through clinical candidate nomination. Design novel compounds with CROs and consultants to address challenges and improve profiles. Integrate multidisciplinary insights from computational chemistry, ADME/Tox, IP, CMC, and pharmacology.

Champion AI, machine learning, and in silico approaches to accelerate design–make–test–analyse cycles. Establish efficient workflows for capturing, integrating, and analysing data from multiple partners. Work closely in cross-functional teams at our Zwijnaarde facility with on-site presence.

Build a new kind of biotech company that pushes innovation across science and people. Seize the opportunity to influence strategy and deliver high-quality drug candidates. Thrive in a human-sized, dynamic, rapidly growing environment focused on patients.

Requirements

PhD (or equivalent) in a relevant chemical science, with 8+ years of experience in biotech or pharma
Proven track record in design and synthesis of small molecules, with experience advancing projects to preclinical development
Ability to work independently and collaboratively within a team
Excellent communication skills, capable of presenting complex scientific concepts to diverse audiences
Fluent in written and spoken English
Demonstrated ability to take initiative and address challenges proactively
Dynamic and practical problem-solving approach with a focus on delivering tangible results

Responsibilities

Lead discovery projects by partnering with lead biologists to progress programs from hit identification through to clinical candidate nomination
Design and optimise molecules by collaborating with CROs and expert consultants to address challenges and improve candidate profiles
Work closely with internal experts in computational chemistry, ADME/Tox, IP, CMC, and pharmacology to integrate multidisciplinary insights
Stay at the forefront of developments in small molecule and peptide therapeutics
Champion the use of AI, machine learning, and in silico approaches to accelerate design–make–test–analyse cycles
Establish efficient workflows for capturing, integrating, and analysing data from multiple partners
Provide clear updates on progress, challenges, and solutions to stakeholders and project teams

Benefits

Opportunity to establish a new role within the organization, contributing to shaping its future direction
Working in a human-sized, dynamic, rapidly growing biotech company providing an engaging work environment
Inclusive environment with equal consideration for employment without discrimination