Postdoctoral Project Research Scientist - Chemical Biology & Antibacterial Drug Discovery

2w2 weeks ago

The Francis Crick Institute

London, GB · Full-time · £45,500 – £45,500

About this role

The Morreale Lab at the Francis Crick Institute seeks a highly motivated Postdoctoral Project Research Scientist with strong synthetic organic chemistry background. Join a multidisciplinary programme focused on novel antibacterial strategies, including targeted protein degradation in bacteria. This role is funded by the END2AMR consortium.

Lead your own project involving design and synthesis of small molecules using medicinal chemistry principles. Collaborate closely with microbiologists, biochemists, and structural biologists to interpret biological data. Depending on needs, contribute to biophysical characterisation of protein-ligand interactions or DNA-encoded library screening.

Work in a highly collaborative translational research environment with academic groups, research institutes, SMEs, and industry partners. Develop innovative antibacterial modalities and delivery technologies. Engage in consortium meetings and support a positive, inclusive lab culture.

This full-time, fixed-term position lasts 2 years on Crick terms. Applications reviewed on rolling basis until filled. Contribute to publications, collaborative reports, and grant activities while leading your project.

Requirements

PhD (or close to completion) in organic chemistry, medicinal chemistry, chemical biology or a related discipline
Strong track record in synthetic organic chemistry, including route design and compound characterisation
Solid understanding of medicinal chemistry concepts and drug discovery workflows
Ability to engage with biological questions and collaborate across disciplines
Excellent organisational, analytical and communication skills
Experience with biophysical techniques (e.g. SPR, ITC, DSF) and DEL screening
Experience in chemical biology and antibacterial drug discovery
Experience working in collaborative consortium-based research environments

Responsibilities

Design and carry out multistep organic syntheses of small molecules and chemical probes
Apply medicinal chemistry principles, including SAR analysis, optimisation of potency and physicochemical properties
Collaborate closely with microbiologists, biochemists and structural biologists to guide compound design and interpretation of biological data
Contribute to biophysical assays and/or DEL screening efforts
Analyse data, maintain clear experimental records and present results within the lab, institute and consortium meetings
Prepare manuscripts for publication and contribute to collaborative reports and grant-related activities
Lead own project and support junior researchers
Contribute to a positive, inclusive and collaborative lab environment

Benefits

Salary from £45,500, subject to skills and experience
Benefits package
Full-time, fixed-term (2 years) position on Crick terms and conditions of employment