Senior Scientist II (Preclinical Bioanalysis)

1w1 week ago

Exelixis

US · Full-time · $132,500 – $188,000

About this role

The Senior Scientist II of preclinical bioanalysis provides preclinical bioanalytical support for the advancement of the biologics portfolio. The incumbent must have strong LCMS-based bioanalysis experience as s/he supports preclinical activities of ongoing and new projects in antibody drug conjugates and other biologics. This role advances biologic oncology programs from discovery to lead selection.

Independently design and execute assay development and qualification of ADCs or other biologics in rodent and NHP matrices. Perform pharmacokinetic sample analyses in support of proof-of-concept studies. Design, implement and manage studies for pharmacokinetic characterization of biologic drug candidates conducted by CROs and in-house as needed.

Critical scientific/technical data analysis and interpretation of experiments. Interact and collaborate with internal departments to deliver quality and timely findings in support of drug candidate advancement. Effectively communicate scientific concepts, findings, and interpretation to multi-disciplinary teams.

Contribute to other translational biology efforts while following company intellectual property and compliance policies. Comply with company health and safety policies and general laboratory practices. If you like wild growth and working with happy, enthusiastic over-achievers, you'll enjoy your career here.

Requirements

Hands-on experience in assay development and sample analysis with LCMS-based bioanalytical assays for biologics
Scientific understanding of in vitro and in vivo pharmacology, PK, and PD concepts in cancer biology
Knowledge and familiarity in LC-MS-based bioanalysis
Demonstrated drive for rigorous scientific excellence and ability to think critically and creatively to identify and solve scientific problems
Ability to work independently with good time management and organization skills
Knowledge and experience of ligand-binding assays and metabolite ID
Excellent written, oral, and interpersonal communication skills
Advanced knowledge in Excel, Word, PowerPoint, PDF, GraphPad Prism

Responsibilities

Independently design and execute assay development and qualification of ADCs or other biologics in rodent and NHP matrices
Perform pharmacokinetic sample analyses in support of proof-of-concept studies on biologic oncology programs from discovery to lead selection
Design, implement and manage studies for pharmacokinetic characterization of biologic drug candidates conducted by CROs and in-house
Conduct critical scientific/technical data analysis and interpretation of experiments
Interact and collaborate with internal departments to deliver quality and timely findings
Effectively communicate scientific concepts, findings, and interpretation to multi-disciplinary teams
Contribute to other translational biology efforts