Associate Scientist - In Vivo Preclinical Pharmacology

1w1 week ago

Eli Lilly and Company

Boston, US · Full-time · $71,250 – $187,000

About this role

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Employees work to discover life-changing medicines, improve disease understanding and management.

At the Lilly Innovation Center in Boston, we explore next-generation therapeutics, new technologies, data analytics, and care models to improve patient health. The Genetic Medicine team challenges conventional wisdom in a start-up environment with large company support, near top academic and industry innovators.

The scientist collaborates with multidisciplinary teams across neuroscience, cardiometabolic, and immunology to perform experiments aiding RNA oligonucleotide drug candidates for next-generation RNA therapies. They bring a strong research track record in biology, analytical mindset, and data-driven decision making.

Daily work includes designing in vivo experiments, rodent handling and dosing, tissue processing with RNA/DNA extraction, and assays like RT-qPCR, Western blot, and ELISA. Support technology development for therapeutic delivery, troubleshoot challenges, and communicate findings in a diverse, inclusive lab environment.

Requirements

B.S. in biology, biochemistry, pharmacology, or related field
1+ years of experience working in the pharmaceutical industry, an academic laboratory, or similar settings
Strong research track record in biology
Analytically minded, systematic, and embrace data-driven decision making
Qualified applicants must be authorized to work in the United States on a full-time basis

Responsibilities

Work with project team leads to design and plan in vivo experiments to support preclinical characterization and evaluation of novel therapeutic molecules
Perform rodent handling and dosing, including subcutaneous (SC), intravenous (IV) and intraperitoneal (IP) dosing
Perform tissue dissection, trimming and processing (e.g. RNA and DNA extraction), collect and process bodily fluids (e.g. blood, urine)
Design, perform and analyze assays interrogating gene expression and protein endpoints (e.g. RT-qPCR, Western blot, JESS, ELISA)
Support technology development for improving the delivery of novel therapeutics to tissues of interest
Assist in troubleshooting technical challenges and provide scientific and technical input to project teams
Provide written and verbal communication of work in lab reports and team meetings
Ensure accurate recording of all practical work in electronic notebook to Lilly procedure quality standards