Scientist - Medicinal Chemistry

2w2 weeks ago

Amgen

Thousand Oaks, US · Full-time · $111,695 – $151,117

About this role

Join Amgen’s Mission of Serving Patients. At Amgen, our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve pioneered biotech against tough diseases, focusing on Oncology, Inflammation, General Medicine, and Rare Disease.

In this vital role, be part of an innovative Medicinal Chemistry group responsible for design, synthesis, and purification of novel compounds for potential clinical drug development. Work within Amgen’s Induced Proximity Platform (IPP) on novel PROTAC approaches to modulate intractable targets. This is an onsite laboratory position at Thousand Oaks.

Our award-winning culture is collaborative, innovative, and science-based. As a lab leader, demonstrate excellent verbal and written communication skills while working in teams. Thrive with passion for challenges and opportunities within them.

Help research, manufacture, and deliver innovative medicines to help patients live longer, fuller, happier lives. Make a lasting impact on patients while transforming your career. Contribute to structure-activity relationships and high-difficulty synthetic chemistry.

Requirements

Doctorate Degree
Master’s degree and 2 years of laboratory experience
Bachelor’s degree and 4 years of laboratory experience
Track record of accomplishments (e.g., peer-reviewed publications)
Demonstrated ability to scout and troubleshoot synthetic routes and perform high difficulty synthetic chemistry
Clear understanding of structural determination using NMR and Mass Spectral techniques
Knowledge of purification methods
Demonstration of good lab practices with particular attention to safety

Responsibilities

Develop, implement, and perform organic reactions for Medicinal Chemistry teams, including troubleshooting synthetic routes and reactions
Scout new synthetic routes and perform high difficulty synthetic chemistry
Contribute to the design of new compounds and development of structure-activity relationships
Perform structural determinations using NMR and mass spectral techniques
Purify compounds using a variety of techniques
Maintain laboratory notebooks and participate in group and project meetings
Present to groups and aid in writing papers and patent applications
Work within Amgen’s Induced Proximity Platform (IPP) using PROTAC modality