Thesis Worker - 60 Credits
2w2 weeks agoAstraZeneca
SE · Internship · SEK 350,000 – SEK 450,000
About this role
Are you passionate about pioneering new models in kidney disease research and driving innovation in drug discovery? Join AstraZeneca’s Renal Biosciences Team for your master’s thesis project. You’ll develop and validate advanced in vitro models of mitochondrial dysfunction in acute kidney injury (AKI).
This project focuses on establishing an AKI model in human renal proximal tubular epithelial cells. Characterize mitochondrial function using the Seahorse XF analyzer and fluorescence microscopy. Assess the model's responsiveness to known modulators of mitochondrial function.
Work onsite at AstraZeneca Gothenburg in a science-led, patient-centered environment. Pursue your areas of interest while developing a broad skillset. Contribute to meaningful projects that deliver real value for patients and the business.
Gain hands-on experience in advanced cell culture and mitochondrial assays. Build expertise in AKI pathogenesis and drug discovery. Strengthen skills in experimental design, data analysis, and scientific writing for future research.
Requirements
- Enrolled in a Swedish University
- Enrolled in a Master's program in biomedical sciences or molecular medicine
- Interest in kidney disease research and mitochondrial biology
- Familiarity with mammalian cell culture techniques
- Knowledge of acute kidney injury pathogenesis
- Basic proficiency in molecular biology methods
Responsibilities
- Develop and validate in vitro models of mitochondrial dysfunction in AKI using human renal proximal tubular epithelial cells
- Establish an AKI model in renal proximal tubular epithelial cells
- Characterize mitochondrial function using Seahorse XF analyzer and fluorescence microscopy
- Assess the model's responsiveness to known modulators of mitochondrial function
- Create a robust and reproducible in vitro model for high-throughput screening of therapeutic compounds
- Optimize experimental conditions for mitochondrial functional assays
- Apply analytical techniques including microscopy, image analysis, Western blot, and qPCR
Benefits
- Work in a Great Place to Work environment
- Push the boundaries of science and fuel entrepreneurial spirit
- Pursue areas of interest while developing broad skillset
- Contribute to projects delivering real value for patients
- Access to advanced assays like Seahorse XF analyzer
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