Thesis Worker - AKI In Vitro Models
2w2 weeks agoAstraZeneca
SE · Internship · SEK 300,000 – SEK 360,000
About this role
Are you passionate about pioneering new models in kidney disease research and driving innovation in drug discovery? Join AstraZeneca’s Renal Biosciences Team for your master’s thesis project. Develop and validate advanced in vitro models of mitochondrial dysfunction in acute kidney injury (AKI).
Establish an AKI model using human renal proximal tubular epithelial cells. Characterize mitochondrial function with Seahorse XF analyzer and fluorescence microscopy. Assess responsiveness to known modulators of mitochondrial function.
Work onsite at AstraZeneca Gothenburg in an environment full of unique opportunities and exciting challenges. Pursue your areas of interest while developing a broad skillset. Contribute to meaningful projects delivering real value for patients and business.
AstraZeneca is a global science-led biopharmaceutical company focused on serious diseases. Dedicated to being a Great Place to Work, empowering employees to push science boundaries. Fuel your entrepreneurial spirit in Renal Biosciences.
Requirements
- Enrolled in a Swedish University
- Enrolled in a Master's program in biomedical sciences or molecular medicine
- Hands-on experience in mammalian cell culture techniques
- Familiarity with mitochondrial functional assays
- Knowledge of acute kidney injury pathogenesis
- Proficiency in molecular biology methods such as Western blot and qPCR
- Skills in microscopy and image analysis
Responsibilities
- Develop and validate in vitro models of mitochondrial dysfunction in acute kidney injury (AKI)
- Establish AKI model in human renal proximal tubular epithelial cells
- Characterize mitochondrial function using Seahorse XF analyzer and fluorescence microscopy
- Assess model's responsiveness to known modulators of mitochondrial function
- Optimize experimental conditions for mitochondrial functional assays
- Apply analytical techniques including microscopy, image analysis, Western blot, and qPCR
- Design experiments, analyze data, and engage in scientific writing
Benefits
- Work on meaningful projects to make an impact for patients
- Pursue areas of interest while developing broad skillset
- Access to advanced assays like Seahorse XF analyzer
- Strong foundation for future research in drug discovery and kidney diseases
- Experience critically evaluating scientific literature
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