Research Fellow - Drug Discovery

2w2 weeks ago

Mass General Brigham

Boston, US · Full-time · $65,000 – $75,000

About this role

Mass General Brigham's Shalhout Lab at Massachusetts Eye and Ear Infirmary seeks a highly motivated postdoctoral fellow. Expertise in small molecule drug discovery, molecular biology, biochemistry, or chemistry is essential. The role involves independent and collaborative research to develop innovative cancer treatments using experimental and computational biology.

Design and perform biophysical and biochemical assays, including protein purification, binding studies, cell reporter assays, and enzymatic assays. Conduct protein-protein and protein-ligand interactions using SPR, ITC, pull-downs, and FRET. Carry out cell-based functional assays such as reporter assays, qPCR, and signaling pathway characterization.

Execute molecular biology techniques including cloning, mutagenesis, and protein expression for structure-function studies. Support hit validation and lead optimization through iterative small molecule testing. Collaborate with medicinal chemistry and computational teams to prioritize candidates and refine drug design.

Work under Principal Investigator supervision with faculty, students, and researchers in a positive environment. Mentor graduate and undergraduate students on methodologies. Prepare publications, presentations, grant proposals, and progress reports to advance research goals.

Requirements

Doctorate in related field of study required
Previous research experience 3-5 years preferred
Expertise in small molecule drug discovery, molecular biology, biochemistry, and/or chemistry
Strong wet-lab skills to design, execute, and interpret experiments
Demonstrated experience in research techniques relevant to the project
Proficient analytical skills and proficiency in statistical software
Excellent written and verbal communication skills
Ability to work independently as well as collaboratively within a team

Responsibilities

Design, plan, and execute research experiments in alignment with departmental goals
Design and perform biophysical and biochemical assays, including protein purification and enzymatic assays
Conduct protein-protein and protein-ligand interactions (e.g., SPR, ITC, pull-downs, FRET)
Carry out cell-based functional assays such as reporter assays, qPCR, and molecular characterization of signaling pathways
Perform molecular biology techniques, including cloning, mutagenesis, and protein expression
Support hit validation and lead optimization through iterative testing of small molecules
Collaborate with medicinal chemistry and computational teams to prioritize candidates
Prepare and publish research findings in peer-reviewed journals and present at conferences