Research Associate - Primary Pharmacology

1w1 week ago

Recursion

GB · Full-time · £41,000 – £52,000

About this role

Recursion is reimagining drug discovery through technology, standardization, and connected data to broaden potential targets. As a research scientist in primary pharmacology, you will design, plan, and execute experiments ensuring assays are fit-for-purpose with quality-controlled data. Leverage cell-based expertise in state-of-the-art labs using diverse assay technologies and automation.

You will develop cell-based and biochemical assays focused on compound characterisation and rapid candidate identification. Implement latest scientific developments and evaluate new technologies. Collaborate with cross-functional teams to produce timely decision-making data for drug discovery programs.

Join the Primary Pharmacology team in Milton Park, Abingdon, comprised of biochemists and cell biology scientists. The team supports projects from target validation to candidate selection through assay development, HTS, routine screening, cell culture, and automation. Work in a dynamic environment optimizing processes for quality and efficiency.

Engage in continual learning and development with exposure to multiple scientific disciplines and the full drug discovery process. Gain hands-on experience driving small molecule therapeutics forward. Deploy advancements to advance from target identification through candidate selection.

Requirements

BSc/MSc/PhD in Oncology, Biology, Biochemistry, Pharmacology, or related discipline; or equivalent experience in pharmaceutical/biotechnology industry
Expertise in in vitro assay development and optimisation
Hands-on experience with cell and enzymatic plate-based assays including BRET, time resolved FRET, luminescent Glo assays, fluorescence intensity/polarisation, flow cytometry, high-content imaging, cell viability/proliferation, second-messenger/signalling pathway, cell binding and target engagement assays
Experience in small molecule high-throughput screening, including dose-response relationship analysis
Ability to work in a highly dynamic, fast-paced cross-functional environment
Proficiency in sterile techniques and cell culture

Responsibilities

Develop cell-based and biochemical assays to drive small molecule therapeutics, focusing on compound characterisation and rapid candidate identification
Implement latest scientific developments and evaluate new technologies
Collaborate with cross-functional project teams to produce timely decision-making data
Engage in continual learning across scientific disciplines and drug discovery from target identification to candidate selection
Design, plan, and execute fit-for-purpose experiments with quality-controlled data
Utilize assay technologies and automation capabilities in state-of-the-art laboratories
Optimize processes for quality and efficiency in primary pharmacology