About this role
Legend Biotech is a global biotechnology company dedicated to treating life-threatening diseases through advanced cell therapies across platforms including autologous and allogenic chimeric antigen receptor T-cell, TCR-T, and NK cell-based immunotherapy. Headquartered in Somerset, New Jersey, with three R&D sites worldwide, they pursue safe, efficacious therapeutics. In global collaboration with Janssen of Johnson & Johnson, they develop and commercialize ciltacabtagene autoleucel for multiple myeloma.
The Preclinical Scientist in the Research and Early Development team performs IND-enabling pharmacology and toxicology studies to support pipeline programs. This role assists preclinical cell therapy studies from discovery to first-in-human trials and marketing authorization. The position involves developing cell-based immunotherapies in a collaborative environment.
Daily work includes designing, optimizing, and implementing IND-enabling studies, executing in vitro and in vivo experiments, and recording data in an electronic laboratory notebook. Contribute to standard operating procedures, report deviations, analyze data, and prepare study reports for regulatory submission. Design in vitro studies to assess efficacy and safety of cell therapies.
Report directly to the Director of Preclinical Pharmacology and Toxicology while working independently. Drive multiple projects with experience in immunology or immune-oncology. Support preparation of scientific and regulatory documents for preclinical studies.
Requirements
- Experience in immunology or immune-oncology to assist preclinical cell therapy studies from discovery to first-in-human trials
- Work independently reporting directly to the Director of Preclinical Pharmacology and Toxicology
- Demonstrate competency and professionalism using the scientific method to design, execute, and troubleshoot in vitro laboratory experiments
- Skillful in driving multiple projects contributing to development of cell-based immunotherapies
- Ability to contribute to creation, review, and approval of prospective standard operating procedures
Responsibilities
- Develop and validate assays to support diverse projects from lead optimization to preclinical pharmacology and toxicology studies for regulatory submission
- Design, optimize, and implement IND-enabling studies
- Execute in vitro and in vivo IND-enabling studies
- Record all experiments in an electronic laboratory notebook and report deviations
- Analyze and report processed data in the form of study reports
- Design and support in vitro IND-enabling studies to assess efficacy and safety of cell therapies
- Support the preparation of scientific and regulatory documents for IND-enabling preclinical studies
Benefits
- Performance-based bonus and/or equity available to employees in eligible roles
- Medical, dental, and vision insurance
- 401(k) retirement plan with company match that vests fully on day one
- Eight weeks of paid parental leave after three months of employment
- Paid time off policy including vacation time, personal time, sick time, floating holidays, and eleven company holidays
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