About this role
Bicycle Therapeutics is a clinical-stage pharmaceutical company pioneering Bicycle® molecules, fully synthetic short peptides constrained for high-affinity target binding in underserved diseases. Your mission is to apply deep expertise in synthetic and medicinal chemistry to design and deliver novel Bicycle® molecules and conjugates. Lead chemistry workstreams to advance the oncology pipeline toward clinical candidates.
Take a leading role in project teams by designing bioactive Bicycle® peptides aligned with the Target Product Profile. Interpret SAR data on activity, selectivity, and DMPK to guide lead compound optimization using structure-based drug design. Contribute to new chemical innovations expanding the company platform capabilities.
Manage chemistry activities at external CROs, developing workplans, tracking progress, and ensuring high-quality compound delivery. Critically evaluate analytical data from NMR, LCMS, and HPLC while troubleshooting synthetic challenges. Collaborate with cross-functional teams across Platform, Biology, DMPK, Pharmacology, and CMC.
Prepare detailed reports, draft patent applications, and present findings in team and management meetings. Embrace Bicycle's culture as Adventurous, Dedicated to our Mission, and One Team. Help deliver the next wave of therapies for patients in oncology and beyond.
Requirements
- Deep expertise in synthetic and medicinal chemistry
- Proficiency in structure-based drug design
- Experience interpreting SAR data including activity, selectivity, and DMPK
- Ability to manage external contract research organizations (CROs)
- Skills in evaluating analytical data from NMR, LCMS, and HPLC
- Capability to troubleshoot synthetic chemistry challenges
- Strong collaboration skills with cross-functional scientific teams
Responsibilities
- Take a leading role in chemistry activities within project teams, contributing to design and synthesis of novel bioactive Bicycle® peptides
- Apply expertise in structure-based drug design to interpret SAR data (activity, selectivity, DMPK) and guide optimization of lead compounds
- Contribute to introduction and development of new chemical innovations and technologies for the company platform
- Manage chemistry activities at external CROs, including workplans, progress tracking, and timely delivery of data and compounds
- Critically evaluate analytical data (NMR, LCMS, HPLC) from CROs and troubleshoot synthetic challenges
- Work collaboratively with cross-functional teams across Platform, Biology, DMPK, Pharmacology, and CMC
- Prepare detailed reports, contribute to patent applications, and present research findings in meetings
Benefits
- Embrace company culture as Adventurous
- Dedicated to our Mission
- One Team environment
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